Immunogenetic predisposition to chronic nonspecific inflammatory bowel disease

• Published in: Ėksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 3; p. 20
• Main Authors: Lazebnik, L B, Kniazev, O V, Iakovleva, M V, Lebedeva, L L, Sagynbaeva, V E, Ruchkina, I N, Mikhaĭlova, Z F, Astrelina, T A, Pukhlikova, T V, Gribanov, I I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2012
• Subjects: Adult; Bronchial Diseases - genetics; Bronchial Diseases - immunology; Case-Control Studies; Chronic Disease; Colitis, Ulcerative - complications; Colitis, Ulcerative - genetics; Colitis, Ulcerative - immunology; Crohn Disease - complications; Crohn Disease - genetics; Crohn Disease - immunology; DNA - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class II - genetics; Humans; Male; Polymorphism, Genetic
• ISSN: 1682-8658

Immunology has grown beyond the classic doctrine of immunity to infectious diseases, and gradually covered the problems of general physiology and pathology, genetics, embryology, transplantation, oncology and many other disciplines. A new direction has appeared--immunogenetics, which should help to answer questions the disposition and/or resistance to disease, as well as influence of environmental factors on implementation of predisposition to the development of pathology. Much attention is paid to investigation of HLA in IBD. These data indicate a significant polymorphism of major histocompatibility complex antigens in this disease in different countries. The aim of our study was to investigate the immunogenetic susceptibility and resistance to the development of ulcerative colitis (UC), and Crohn's disease (CD), the character of their flow, as well as the associated extraintestinal manifestations, in particular predisposition development of bronchial obstruction (BO) in patients with inflammatory bowel disease (IBD). A study of DNA frozen blood samples of 75 patients with IBD of both sexes has been conducted. The obtained results have been compared with the results of the study 1700 of samples of umbilical cord blood of newborns (apparently healthy children), born at 37-41 weeks' gestation in Moscow (control). The group of patients with UC revealed a positive association of HLA specificities-B*38, HLA-Cw*12 and HLA-DRV1*15, which can be regarded as potentially high risk of developing the disease. The presence of the specificity of HLA-DQV1*02 can be considered as a factor in resistance to the development of UC. High risk of developing Crohn's disease among residents of Moscow associated with groups of alleles of HLA B*41, HLA-B*56, HLA-Cw*05, HLA-Cw*08, HLA-DRV1*01, HLA-DRV1*11, HLA-DQV1*04, and the presence of specificity of HLA-DQV1*05 can be considered as a factor of resistance to the development of BC. High risk of developing BO in patients with IBD is associated with specificities HLA-DQB1*02, DQB1*03, DRB1*15.