The effect of Helicobacter pylori infection on duodenal bulbar microbiota in children with duodenal ulcer

• Published in: Zhonghua er ke za zhi Vol. 61; no. 1; p. 49
• Main Authors: Zheng, W, Peng, K R, Li, F B, Zhao, H, Jiang, M Z
• Format: Journal Article
• Language: Chinese
• Published: China 02.01.2023
• Subjects: Child; Duodenal Ulcer - diagnosis; Female; Helicobacter Infections - complications; Helicobacter pylori - genetics; Humans; Male; Microbiota; Prospective Studies
• ISSN: 0578-1310
• DOI: 10.3760/cma.j.cn112140-20220328-00251

To investigate the characteristics of duodenal bulbar microbiota in children with duodenal ulcer and (Hp) infection. This prospective cohort study enrolled 23 children with duodenal ulcers diagnosed by gastroscopy who were admitted to the Children's Hospital of Zhejiang University School of Medicine due to abdominal pain, abdominal distension, and vomiting from January 2018 to August 2018. They were divided into Hp positive and Hp negative groups according to the presence or absence of Hp infection. Duodenal bulbar mucosa was sampled to detect the bacterial DNA by high-throughput sequencing. The statistical difference in α diversity and β diversity, and the relative abundance in taxonomic level between the two groups were compared. Microbial functions were predicted using the software PICRUSt. test, Rank sum test or χ test were used for comparison between the two groups. A total of 23 children diagnosed with duodenal ulcer were enrolled in this study, including 15 cases with Hp infection ((11.2±3.3) years of