THE PROTECTIVE EFFECTS OF SELENIUM-ENRICHED HYDROPONIC RADISH ON PARACETAMOL-INDUCED LIVER DAMAGE IN RATS

Paracetamol-induced liver toxicity in rats is a well-studied model for liver damage. The present study investigates the morphological changes in hepatic blood vessels and the protective effects of hydroponically grown Radish (Raphanus sativus L.) pretreatment in rats with paracetamol-induced liver d...

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Bibliographic Details
Published inGeorgian medical news no. 352-353; p. 168
Main Authors Darbinyan, L, Danielyan, M, Chavushyan, V, Simonyan, K, Babakhanyan, M, Hambardzumyan, L, Manukyan, L, Isoyan, A, Karapetyan, K, Sarkisian, V, Hovhannisyan, L
Format Journal Article
LanguageEnglish
Published Georgia (Republic) 01.07.2024
Subjects
Acetaminophen - adverse effects
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Chemical and Drug Induced Liver Injury - pathology
Chemical and Drug Induced Liver Injury - prevention & control
Hydroponics
Liver - drug effects
Liver - pathology
Male
Raphanus - chemistry
Rats
Rats, Wistar
Selenium - pharmacology
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Summary:Paracetamol-induced liver toxicity in rats is a well-studied model for liver damage. The present study investigates the morphological changes in hepatic blood vessels and the protective effects of hydroponically grown Radish (Raphanus sativus L.) pretreatment in rats with paracetamol-induced liver damage. The results indicate significant alterations in vascular morphology and liver enzyme levels, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which serve as indicators of hepatotoxicity. The findings suggest that hydroponic Radish may mitigate the adverse effects of paracetamol on liver health, highlighting the importance of dietary components in preventing micronutrient deficiencies and promoting overall health.
ISSN:1512-0112