Local upregulation of colonic angiotensin II receptors enhances potassium excretion in chronic renal failure

The role of angiotensin II (ANG II) in colonic secretion of K+ was examined in rats with chronic renal failure (CRF). The basal net secretory flux of 86Rb+ (as a tracer for K+) across the CRF distal colon was reversed to an absorptive flux by injecting the rats with the AT1, receptor antagonist, los...

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 43; no. 2; pp. F275 - F282
Main Authors HATCH, M, FREEL, R. W, VAZIRI, N. D
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.1998
Subjects
Biological and medical sciences
Colon
Hormones
Kidneys
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Potassium
Renal failure
Rodents
Kidney disease
Urinary system disease
Potassium Cations
Rat
Digestive system
Secretion
Biological transport
Rodentia
Ion transport
Small intestine
Ileum
Renin angiotensin system
Vertebrata
Regulation(control)
Mammalia
Absorption
Jejunum
Losartan
Renal failure
Peptidergic receptor
Antagonist
Angiotensin II
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Summary:The role of angiotensin II (ANG II) in colonic secretion of K+ was examined in rats with chronic renal failure (CRF). The basal net secretory flux of 86Rb+ (as a tracer for K+) across the CRF distal colon was reversed to an absorptive flux by injecting the rats with the AT1, receptor antagonist, losartan.
ISSN:1931-857X
1522-1466