Expression of CD226 in the small intestinal group 3 innate lymphoid cells (ILC3) in mice

Objective To observe the expression of adhesion molecule CD226 on the small intestinal group 3 innate lymphoid cells (ILC3) in mice. Methods The bioinformatics was used to analyze the expression of CD226 on murine ILCs. Small intestinal mucosal lamina propria lymphocytes (LPL) were isolated from wil...

Full description

Saved in:
Bibliographic Details
Published inXi bao yu fen zi mian yi xue za zhi Vol. 40; no. 1; p. 1
Main Authors Yang, Lu, Ma, Jingchang, Liu, Yitian, Wang, Tingting, Wang, Yuling, Zhuang, Ran, Zhang, Zhengxiang
Format Journal Article
LanguageChinese
Published China 01.01.2024
Subjects
Animals
Colitis - chemically induced
Immunity, Innate
Intestine, Small
Lymphocytes
Mice
Mice, Inbred C57BL
Online AccessGet more information

Cover

More Information
Summary:Objective To observe the expression of adhesion molecule CD226 on the small intestinal group 3 innate lymphoid cells (ILC3) in mice. Methods The bioinformatics was used to analyze the expression of CD226 on murine ILCs. Small intestinal mucosal lamina propria lymphocytes (LPL) were isolated from wild-type C57BL/6J mice, and the expression of CD226 on ILC1 and ILC3 was detected by flow cytometry. A mouse model of dextran sulfate sodium (DSS)-induced colitis was constructed to observe the changes in the expression of CD226 on ILC3. Results Both ILC1 and ILC3 in the mice small intestine expressed CD226 molecules; the proportion of ILC3 was reduced, while the expression level of CD226 on ILC3 was increased in the colitis model. Conclusion CD226 is expressed on the small intestines of mice, and although the proportion of ILC3 decreases in the DSS-induced colitis, the expression of CD226 on ILC3 increases.
ISSN:1007-8738