Ventilator-associated pneumonia among premature infants <34 weeks' gestational age in neonatal intensive care unit in China: a multicenter study

• Published in: Zhonghua er ke za zhi Vol. 55; no. 3; p. 182
• Main Authors: Li, S J, Yan, S Y, Zhou, Y, Han, K L E E, Guo, W L, Xia, Q, Vibhuti, S P, Wang, J Z, Ji, S W, Yang, S H A H, Yang, S N, Shan, C, Liu, C Y, Yi, Z Z, Liu, R B, Lin, L, Wang, B, He, J Q, Li, Z L, Pan, Y, Guo, L, Chen, M X, Liu, X N, Li, L, Xiong, C Q, Qi, Q, Hei, X Y, Cao, J, Jiang, Y J, Zhang, M Y, Shoo, Y
• Format: Journal Article
• Language: Chinese
• Published: China 02.03.2017
• Subjects: Birth Weight; China; Female; Gestational Age; Gram-Negative Bacteria; Hospitals, Pediatric; Humans; Incidence; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Klebsiella pneumoniae; Male; Pneumonia, Ventilator-Associated; Prospective Studies; Ventilators, Mechanical; Pathogen; Infant, newborn; Multicenter study; Pneumonia, ventilator-associated
• ISSN: 0578-1310
• DOI: 10.3760/cma.j.issn.0578-1310.2017.03.004

To investigate the incidence and pathogen distribution of ventilator-associated pneumonia (VAP) among preterm infants admitted to level Ⅲ neonatal intensive care units (NICU) in China. A prospective study was conducted in 25 level Ⅲ NICU, enrolling all preterm infants <34 weeks gestational age admitted to the participating NICU within the first 7 days of life from May 2015 to April 2016. Chi-square test, test and Mann-Whitney test were used for statistical analysis. A total of 7 918 patients were enrolled, within whom 4 623(58.4%) were males. The birth weight was (1 639±415) g and the gestational age was (31.4±2.0) weeks; 4 654(58.8%) infants required non-invasive mechanical ventilation and 2 154(27.2%) required intubation. Of all the mechanically ventilated patients, VAP occurred in 95 patients. The overall VAP rate was 7.0 episodes per 1 000 ventilator days, varying from 0 to 34.4 episodes per 1 000 ventilator days in different centers. The incidence of VAP was 9.6 and 6.0 per 1 000 ventilator days in child