A novel method for non-invasive mechanical ablation of prostate tumors using pulsed focused ultrasound

of the study: demonstrate the feasibility of non-invasive mechanical disintegration of human prostate tissue using pulsed high-intensity focused ultrasound (pHIFU), a method termed boiling histotripsy. An ultrasound experimental system was developed for producing localized mechanical lesions in ex v...

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Bibliographic Details
Published inUrologii͡a︡ (Moscow, Russia : 1999) no. 6; p. 67
Main Authors Khokhlova, V A, Rosnitskiy, P B, Tsysar, S A, Buravkov, S V, Sapozhnikov, O A, Karzova, M M, Khokhlova, T D, Maxwell, A D, Gaifullin, N M, Kadrev, A V, Okhobotov, D A, Kamalov, A A, Schade, G R
Format Journal Article
LanguageRussian
Published Russia (Federation) 31.12.2019
Subjects
High-Intensity Focused Ultrasound Ablation
Humans
Male
Pilot Projects
Prostatic Neoplasms - therapy
Ultrasonography
HIFU
prostate cancer
non-invasive procedure
histology
boiling histotripsy
benign prostatic hyperplasia
ultrasound
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Summary:of the study: demonstrate the feasibility of non-invasive mechanical disintegration of human prostate tissue using pulsed high-intensity focused ultrasound (pHIFU), a method termed boiling histotripsy. An ultrasound experimental system was developed for producing localized mechanical lesions in ex vivo biological tissue samples under ultrasound guidance. A series of experiments was carried out to create small single-focus lesions (volume < 2 mm3) and one large lesion (volume > 50 mm3) in ex vivo prostate tissue samples. After irradiation, two samples were bisected to visualize the region of destruction; the other tissue samples were examined histologically. During pHIFU irradiation under B-mode ultrasound guidance, a region of increased echogenicity caused by formation of vapor-gas bubbles was visualized in the target region. After exposure, small and large lesions filled with a suspension of liquefied tissue were observed. Histological examination confirmed that the prostate tissue in the focal region was disintegrated into subcellular fragments. A pilot study showed the feasibility of using boiling histotripsy as a non-invasive method for treating prostate diseases.
ISSN:1728-2985