Effects of a unique conjugate of α-lipoic acid and γ-linolenic acid on insulin action in obese Zucker rats

The purpose of this study was to assess the individual and interactive effects of the antioxidant alphax-lipoic acid (LPA) and the n-6 essential fatty acid gamma-linolenic acid (GLA) on insulin action in insulin-resistant obese Zucker rats. LPA, GLA, and a unique conjugate consisting of equimolar pa...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 47; no. 2; pp. R453 - R459
Main Authors PETH, J. A, KINNICK, T. R, YOUNGBLOOD, E. B, TRITSCHLER, H. J, HENRIKSEN, E. J
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.2000
Subjects
Biological and medical sciences
Insulin
Medical sciences
Metabolic diseases
Metabolism
Muscular system
Obesity
Rodents
Lipoic acid
Obesity
Pancreatic hormone
Rat
Biological transport
Rodentia
Tolerance
Lipids
Glucose
Antioxidant
Striated muscle
Fatty acids
Insulin
γ-Linolenic acid
Metabolic disorder
Vertebrata
Mammalia
n-6 fatty acid
Animal
Unsaturated fatty acid
Online AccessGet full text

Cover

More Information
Summary:The purpose of this study was to assess the individual and interactive effects of the antioxidant alphax-lipoic acid (LPA) and the n-6 essential fatty acid gamma-linolenic acid (GLA) on insulin action in insulin-resistant obese Zucker rats. LPA, GLA, and a unique conjugate consisting of equimolar parts of LPA and GLA (LPA-GLA) were administered for 14 days at 10, 30, or 50 mg-kg body wt-1 - day-1.
ISSN:0363-6119
1522-1490