Application of cluster randomization design in vaccine clinical trials

When the coverage of the vaccinated people reaches a certain percentage of the population, the herd protection will protect the unvaccinated persons. However, the traditional clinical evaluation of vaccines performing individual randomized design fails to evaluate the herd protection of vaccines. Co...

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Bibliographic Details
Published inZhōnghuá liúxíngbìng zázhì Vol. 42; no. 12; p. 2221
Main Authors Gao, S Y, Li, J X, Jin, P F, Zhu, F C
Format Journal Article
LanguageChinese
Published China 10.12.2021
Subjects
China
Humans
Immunity, Herd
Random Allocation
Vaccines
China
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Summary:When the coverage of the vaccinated people reaches a certain percentage of the population, the herd protection will protect the unvaccinated persons. However, the traditional clinical evaluation of vaccines performing individual randomized design fails to evaluate the herd protection of vaccines. Compared with the individual randomized design, the cluster-randomized design can determine the overall protection by the vaccine more comprehensively. It has become increasingly common to perform a cluster-randomized design in clinical trials of vaccines in Phase Ⅲ and Ⅳ clinical trials. However, little is known about the application of cluster randomized design in vaccine clinical trials in China. We, at this moment, do a review of the application of random cluster design in vaccine clinical trials and provide references for future research in China.
ISSN:0254-6450
DOI:10.3760/cma.j.cn112338-20210622-00491