Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo

Nitric oxide (NO) in the nucleus tractus solitarii (NTS) plays an important role in regulating sympathetic nerve activity. The aims of this study were to determine whetehr the activation of N-methyl-D-aspartate (NMDA) receptors in the NTS facilitates the release of L-glutamate (Glu) via NO productio...

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Bibliographic Details
Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 49; no. 5; pp. R1285 - R1291
Main Authors MATSUO, Isamu, HIROOKA, Yoshitaka, HIRONAGA, Kiyoshi, ESHIMA, Kenichi, SHIGEMATSU, Hideaki, SHIHARA, Miwako, SAKAI, Koji, TAKESHITA, Akira
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.05.2001
Subjects
Amino acids
Biological and medical sciences
Blood pressure
Fundamental and applied biological sciences. Psychology
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Nervous system
Vertebrates: nervous system and sense organs
Cardiovascular control
Rat
Enzyme
Rodentia
Central nervous system
Glutamate receptor
Glutamate
Nitric-oxide synthase
Solitary nucleus
Heart rate
Vertebrata
Bradycardia
Mammalia
Nitric oxide
Arterial hypotension
Excitatory aminoacid
Neurotransmitter
Blood pressure
Hemodynamics
Oxidoreductases
NMDA receptor
Release
Brain (vertebrata)
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Summary:Nitric oxide (NO) in the nucleus tractus solitarii (NTS) plays an important role in regulating sympathetic nerve activity. The aims of this study were to determine whetehr the activation of N-methyl-D-aspartate (NMDA) receptors in the NTS facilitates the release of L-glutamate (Glu) via NO production, and, if so, to determine whether this mechanism is involved in the depressor and bradycardic responses evoked by NMDA.
ISSN:0363-6119
1522-1490