Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo
Nitric oxide (NO) in the nucleus tractus solitarii (NTS) plays an important role in regulating sympathetic nerve activity. The aims of this study were to determine whetehr the activation of N-methyl-D-aspartate (NMDA) receptors in the NTS facilitates the release of L-glutamate (Glu) via NO productio...
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Published in | American journal of physiology. Regulatory, integrative and comparative physiology Vol. 49; no. 5; pp. R1285 - R1291 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
American Physiological Society
01.05.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Nitric oxide (NO) in the nucleus tractus solitarii (NTS) plays an important role in regulating sympathetic nerve activity. The aims of this study were to determine whetehr the activation of N-methyl-D-aspartate (NMDA) receptors in the NTS facilitates the release of L-glutamate (Glu) via NO production, and, if so, to determine whether this mechanism is involved in the depressor and bradycardic responses evoked by NMDA. |
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ISSN: | 0363-6119 1522-1490 |