Amiodarone and thyroid

Amiodarone is a widely used antiarrythmic drug and can lead either to hypothyroidism or hyperthyroidism due to its molecular structure which is similar to levothyroxin. Amiodarone induced hypothyroidism can be treated easely with hormonal subsitution. Hyperthyroidism is more challenging. There exist...

Full description

Saved in:
Bibliographic Details
Published inTherapeutische Umschau Vol. 68; no. 6; p. 309
Main Authors Capraro, Joël, Thalmann, Sébastien
Format Journal Article
LanguageGerman
Published Switzerland 01.06.2011
Subjects
Amiodarone - adverse effects
Anti-Arrhythmia Agents - adverse effects
Hormone Replacement Therapy - methods
Humans
Hyperthyroidism - chemically induced
Hyperthyroidism - drug therapy
Hyperthyroidism - prevention & control
Hypothyroidism - chemically induced
Hypothyroidism - drug therapy
Hypothyroidism - prevention & control
Thyroid Hormones - therapeutic use
Treatment Outcome
Online AccessGet more information

Cover

More Information
Summary:Amiodarone is a widely used antiarrythmic drug and can lead either to hypothyroidism or hyperthyroidism due to its molecular structure which is similar to levothyroxin. Amiodarone induced hypothyroidism can be treated easely with hormonal subsitution. Hyperthyroidism is more challenging. There exist two forms of amiodarone-induced Hyperthyroidism (AIT): AIT type 1 is directly related to the iodine compound of amiodarone and responds to thyreostatic therapy. Type 2 is a consequence of the direct toxicity of amiodarone to the thyroid gland and is treated primarily with glucocorticoids. However, this differentiation often is impossible in clinical settings and a pragmatic approach is needed.
ISSN:0040-5930
DOI:10.1024/0040-5930/a000170