Influence of serum cortisol levels on glycemic control in children with type 1 diabetes

The association between plasma glucose (PG), HbA1c and serum cortisol levels in children with type 1 diabetes was investigated to determine the influence of serum cortisol on their glycemic control. A total of 45 children, aged 10-15 years, with type 1 diabetes for at least 3 years of diabetes were...

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Published inJournal of the Egyptian Society of Parasitology Vol. 41; no. 3; p. 777
Main Authors Mosbah, Amira A Abd El-Rahman, Abd-Ellatif, Nahla A Bahgat, Sorour, Ehab Ibrahim
Format Journal Article
LanguageEnglish
Published Egypt 01.12.2011
Subjects
Adolescent
Blood Glucose - physiology
Child
Diabetes Mellitus, Type 1 - blood
Female
Glycated Hemoglobin A - metabolism
Humans
Hydrocortisone - blood
Male
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Summary:The association between plasma glucose (PG), HbA1c and serum cortisol levels in children with type 1 diabetes was investigated to determine the influence of serum cortisol on their glycemic control. A total of 45 children, aged 10-15 years, with type 1 diabetes for at least 3 years of diabetes were studied. Most of them did not have pancreatic beta-cell function. The cortisol levels among all patients were stratified according to fasting plasma glucose levels (50-99, 100-199, 200-299, & > or = 300 mg/dL), and the HbAlc levels (<7.0, 7.0-7.9, 8.0-8.9, & > or = 9%). The mean fasting PG, HbA1c and serum cortisol levels were 174 +/- 97 mg/dL, 7.7 +/- 1.3% and 23.04 +/- 16.6 ug/dl, respectively. The cortisol levels were highly correlated with PG levels (r =0.553, P < 0.0001) and mildly correlated with HbA1c levels (r=0.301, P=0.0192). Patients with high PG levels gave significantly higher cortisol levels as compared to those with lower PG levels (18.4 +/- 7.3, 26.8 +/- 18.3, 31.4 +/- 17.0 & 36.3 +/- 17.2ug/dl, P=0.0009). There were no significant differences in serum cortisol levels among patients stratified according to HbA1c levels (P=0.1566), however, patients with HbA1c levels > or = 9% had significantly higher cortisol levels than those with HbA1c levels<7% (32.6 +/- 14.4 vs. 21.8 +/- 11.3ug/dl, P=0.0291).
ISSN:1110-0583