Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor

Caspases have been implicated in the effector process of apoptosis in several systems including the Fas-Fas ligand pathway. We previously demonstrated that excessive apoptosis of lung epithelial cells and the Fas-Fas ligand pathway were essential in the pathogenesis of bleomycin-induced pneumopathy...

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Published inAmerican journal of physiology. Lung cellular and molecular physiology Vol. 24; no. 2; pp. L316 - L325
Main Authors KUWANO, Kazuyoshi, KUNITAKE, Ritsuko, MAEYAMA, Takashige, HAGIMOTO, Naoki, KAWASAKI, Masayuki, MATSUBA, Tokuji, YOSHIMI, Michihiro, INOSHIMA, Ichiro, YOSHIDA, Koichiro, HARA, Nobuyuki
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.2001
Subjects
Anatomy & physiology
Biological and medical sciences
Cells
Injuries
Lungs
Medical sciences
Pharmacology. Drug treatments
Pneumonia
Respiratory system
Rodents
Studies
Lung disease
Animal model
Respiratory disease
Lung
Rodentia
Enzyme inhibitor
Respiratory system
Vertebrata
Experimental disease
Mammalia
Bleomycin
Treatment
Mouse
Cell death
Glycopeptide
Animal
Fibrosis
Epithelial cell
Pneumopathy
Apoptosis
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Summary:Caspases have been implicated in the effector process of apoptosis in several systems including the Fas-Fas ligand pathway. We previously demonstrated that excessive apoptosis of lung epithelial cells and the Fas-Fas ligand pathway were essential in the pathogenesis of bleomycin-induced pneumopathy in mice.
ISSN:1040-0605
1522-1504