Diagnostic value of p16INK4a in squamous intraepithelial lesion in gynecologic cytology

To study the diagnostic value of p16(INK4a) in squamous intraepithelial lesion in gynecologic cytology and its relationship with types of human papillomavirus (HPV). 88 liquid-based gynecologic cytology cases with histologic correlation, including 20 cases of cervicitis, 18 cases of low-grade squamo...

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Bibliographic Details
Published inZhonghua bing li xue za zhi Vol. 36; no. 8; p. 521
Main Authors Mei, Ping, Liu, Yan-hui, Zhuang, Heng-guo, Luo, Xin-lan, Xiao, Ke-lin
Format Journal Article
LanguageChinese
Published China 01.08.2007
Subjects
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - virology
Cervical Intraepithelial Neoplasia - diagnosis
Cervical Intraepithelial Neoplasia - metabolism
Cervical Intraepithelial Neoplasia - virology
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Diagnosis, Differential
Female
Genotype
Humans
Immunohistochemistry
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections
Polymerase Chain Reaction
Sensitivity and Specificity
Uterine Cervical Dysplasia - diagnosis
Uterine Cervical Dysplasia - metabolism
Uterine Cervical Dysplasia - virology
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - metabolism
Uterine Cervical Neoplasms - virology
Uterine Cervicitis - diagnosis
Uterine Cervicitis - metabolism
Uterine Cervicitis - virology
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Summary:To study the diagnostic value of p16(INK4a) in squamous intraepithelial lesion in gynecologic cytology and its relationship with types of human papillomavirus (HPV). 88 liquid-based gynecologic cytology cases with histologic correlation, including 20 cases of cervicitis, 18 cases of low-grade squamous intraepithelial lesion (LSIL), 34 cases of high-grade squamous intraepithelial lesion (HSIL) and 16 cases of squamous cell carcinoma (SCC), were enrolled into the study. Immunocytochemistry for p16(INK4a) protein and polymerase chain reaction-based HPV DNA testing (for HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68, as well as HPV types 6, 11, 42, 43 and 44) were performed. The rate of expression of p16(INK4a) protein was 0, 27.8%, 100% and 100% in the cervicitis group, LSIL group, HSIL group and SCC group, respectively. The expression was significantly higher in the latter 3 groups than that in the cervicitis group (P < 0.01). Besides, the expression was significantly higher in cases as
ISSN:0529-5807