Transcriptional regulator of carbon catabolite repression CreA in filamentous fungus

Penicillium canescens strain F178 is a natural producer of beta-galactosidase and endo-1,4-beta-xylanase. Tanscription of genes bgaS and xylA coding for these proteins is subject to carbon catabolite repression which proceed mainly in filamentous fungi by transcriptional repressor CreA. creA gene of...

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Published inMolekuliarnaia biologiia Vol. 44; no. 4; p. 677
Main Authors Chulkin, A M, Vavilova, E A, Benevolenskiĭ, S V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2010
Subjects
beta-Galactosidase - biosynthesis
beta-Galactosidase - genetics
Carbon - metabolism
Endo-1,4-beta Xylanases - biosynthesis
Endo-1,4-beta Xylanases - genetics
Fungal Proteins - genetics
Fungal Proteins - metabolism
Gene Expression Regulation, Enzymologic - physiology
Gene Expression Regulation, Fungal - physiology
Penicillium - genetics
Penicillium - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
Transcription, Genetic - physiology
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Summary:Penicillium canescens strain F178 is a natural producer of beta-galactosidase and endo-1,4-beta-xylanase. Tanscription of genes bgaS and xylA coding for these proteins is subject to carbon catabolite repression which proceed mainly in filamentous fungi by transcriptional repressor CreA. creA gene of P. canescens was cloned. It was demonstrated that creA transcription is also subject to carbon catabolite repression. CreA protein remains intranuclear independently of nature of carbon source and glucose concentration in culture medium. In vitro experiments confirm availability of four CreA-binding sites in bgaS promoter, four sites in xylA promoter and one such site in creA promoter.
ISSN:0026-8984