Keratinocyte growth factor attenuates hydrostatic pulmonary edema in an isolated, perfused rat lung model

Hydrostatic pulmonary edema is a common complication of congestive heart failure, resulting in substantial morbidity and mortality. Keratinocyte growth factor (KGF) is a mitogen for type II alveolar epithelial and microvascular cells.

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 49; no. 3; pp. H1311 - H1317
Main Authors WELSH, David A, GUERY, Benoit P. H, DEBOISBLANC, Bennett P, DOBARD, Elizabeth P, CREUSY, Colette, MERCANTE, Donald, NELSON, Steve, SUMMER, Warren R, MASON, Carol M
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.03.2001
Subjects
Biological and medical sciences
Heart failure
Lungs
Medical research
Medical sciences
Pharmacology. Drug treatments
Respiratory system
Rodents
Animal model
Rat
Lung
Cardiovascular disease
Respiratory system
Isolated organ
Microcirculation
Heart disease
Blood vessel
Complication
Pretreatment
Heart failure
Lung disease
Alveolar type II cell
Edema
Cell permeability
Respiratory disease
Rodentia
Keratinocyte growth factor
Pulmonary capillary
Vertebrata
Mammalia
Animal
Hydrostatic pressure
Circulatory system
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Summary:Hydrostatic pulmonary edema is a common complication of congestive heart failure, resulting in substantial morbidity and mortality. Keratinocyte growth factor (KGF) is a mitogen for type II alveolar epithelial and microvascular cells.
ISSN:0363-6135
1522-1539