Aspects of practical diagnosis in perinatal post-hypoxic cardiomiopathy

Retrospectively the Perinatal Post-Hypoxic Cardiac disorder, was researched in 32 newborn (ages 0-14 days), having a normal weight, with hypoxia at birth, Apgar score 3-7, requiring resuscitation at birth. The patients did not show signs of major cardiac suffering, except a systolic murmur, the neur...

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Bibliographic Details
Published inRevista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 112; no. 4; p. 942
Main Authors Mitrea, Geta, Dimitriu, A G, Stamatin, Maria
Format Journal Article
LanguageRomanian
Published Romania 01.10.2008
Subjects
Asphyxia Neonatorum - complications
Cardiomegaly - diagnosis
Cardiomegaly - drug therapy
Cardiomegaly - etiology
Cardiomegaly - physiopathology
Diagnosis, Differential
Diastole
Diuretics - therapeutic use
Echocardiography, Doppler
Electrocardiography
Heart Conduction System - physiopathology
Humans
Infant, Newborn
Retrospective Studies
Severity of Illness Index
Spironolactone - therapeutic use
Treatment Outcome
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
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Summary:Retrospectively the Perinatal Post-Hypoxic Cardiac disorder, was researched in 32 newborn (ages 0-14 days), having a normal weight, with hypoxia at birth, Apgar score 3-7, requiring resuscitation at birth. The patients did not show signs of major cardiac suffering, except a systolic murmur, the neurologic manifestations prevailing. The investigations showed: cardiomegaly (46.9%); ECG: repolarization disorders of the left ventricle (LV) (43.5%); echocardiographic modifications in 67.2% of cases, mainly hypertrophic cardiomyopathy with septal predominance (59.3%) and LV diastolic dysfunction. The treatment with spironolactone generated the significant decrease of the septal myocardial hypertrophy and of the tricuspidien insufficiency, with the normalization of the LV diastolic function. The echocardiographic examination, as the main method of diagnosis and follow up of the cardiomiopathy induced by the perinatal hypoxia has to be performed right in the 1st week of life and later on up to the cure of the morphologic and functional cardiac modifications.
ISSN:0048-7848