Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

• Published in: American Journal of Physiology: Cell Physiology Vol. 48; no. 3; pp. C670 - C681
• Main Authors: HIMMS-HAGEN, J, MELNYK, A, ZINGARETTI, M. C, CERESI, E, BARBATELLI, G, CINTI, S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.09.2000
• Subjects: Biological and medical sciences; Cellular biology; Fundamental and applied biological sciences. Psychology; Obesity; Proteins; Rodents; Tissues; Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue; Cell proliferation; Adipocyte; Uncoupling protein; White adipose tissue; Rat; Rodentia; β3-Adrenergic receptor; Brown adipose tissue; Vertebrata; Mitochondria; Mammalia; Thermogenesis; Ultrastructure

Himms-Hagen et al propose that multilocular adipocytes present at seven days of CL-316243 treatment have two origins. First, most come from convertible unilocular adipocytes that become multilocular and make many mitochondria that contain UCP3, and second, some come from a cell that gives rise to mo...