Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

Himms-Hagen et al propose that multilocular adipocytes present at seven days of CL-316243 treatment have two origins. First, most come from convertible unilocular adipocytes that become multilocular and make many mitochondria that contain UCP3, and second, some come from a cell that gives rise to mo...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 48; no. 3; pp. C670 - C681
Main Authors HIMMS-HAGEN, J, MELNYK, A, ZINGARETTI, M. C, CERESI, E, BARBATELLI, G, CINTI, S
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2000
Subjects
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Obesity
Proteins
Rodents
Tissues
Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
Cell proliferation
Adipocyte
Uncoupling protein
White adipose tissue
Rat
Rodentia
β3-Adrenergic receptor
Brown adipose tissue
Vertebrata
Mitochondria
Mammalia
Thermogenesis
Ultrastructure
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Summary:Himms-Hagen et al propose that multilocular adipocytes present at seven days of CL-316243 treatment have two origins. First, most come from convertible unilocular adipocytes that become multilocular and make many mitochondria that contain UCP3, and second, some come from a cell that gives rise to more typical brown adipocytes that express UCP1.
ISSN:0363-6143
1522-1563