Modulation of early [Ca2+]i rise in metabolically inhibited endothelial cells by xestospongin C

When energy metabolism is disrupted, endothelial cells lose Ca2+ from endoplasmic reticulum (ER) and the cytosolic Ca2+ concentration ([Ca2+]i) increases. The importance of glycolytic energy production and the mechanism of Ca2+ loss from the ER were analyzed.

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 49; no. 3; pp. H1002 - H1010
Main Authors SCHÄFER, M, BAHDE, D, BOSCHE, B, LADILOV, Y, SCHÄFER, C, PIPER, H. M, NOLL, T
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.03.2001
Subjects
Biological and medical sciences
Blood vessels and receptors
Cells
Fundamental and applied biological sciences. Psychology
Medical research
Metabolism
Vertebrates: cardiovascular system
Oxygen
Endothelial cell
Environmental factor
Inositol phosphate
Permeability
Cytosol
Artery
Pig
Vertebrata
Mammalia
Calcium ion
Blood vessel
Animal
Aorta
Hypoxia
Circulatory system
Artiodactyla
Antagonist
Intracellular
Endoplasmic reticulum
Ungulata
Biological receptor
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Summary:When energy metabolism is disrupted, endothelial cells lose Ca2+ from endoplasmic reticulum (ER) and the cytosolic Ca2+ concentration ([Ca2+]i) increases. The importance of glycolytic energy production and the mechanism of Ca2+ loss from the ER were analyzed.
ISSN:0363-6135
1522-1539