Effect of alendronate on bone tissue status of senescence-accelerated OXYS rats

• Published in: Advances in gerontology = Uspekhi gerontologii Vol. 24; no. 1; p. 143
• Main Authors: Muraleva, N A, Sadovoĭ, M A, Kolosova, N G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2011
• Subjects: Aging, Premature - blood; Aging, Premature - metabolism; Aging, Premature - prevention & control; Alendronate - administration & dosage; Alendronate - therapeutic use; Animals; Bone and Bones - drug effects; Bone and Bones - metabolism; Bone Density - drug effects; Bone Density Conservation Agents - administration & dosage; Bone Density Conservation Agents - therapeutic use; Calcium - blood; Calcium - urine; Female; Male; Osteocalcin - blood; Osteoporosis - blood; Osteoporosis - metabolism; Osteoporosis - prevention & control; Rats; Rats, Wistar; Sex Characteristics

The purpose of this research was to study the effect of Alendronate on bone mineral density (BMD) and markers of bone turnover in male and female Wistar rats and senescence-accelerated OXYS rats with early development of osteoporosis. The animals were treated with Alendronate (0.84 mg/kg) during 2 m...