Effect of alendronate on bone tissue status of senescence-accelerated OXYS rats

The purpose of this research was to study the effect of Alendronate on bone mineral density (BMD) and markers of bone turnover in male and female Wistar rats and senescence-accelerated OXYS rats with early development of osteoporosis. The animals were treated with Alendronate (0.84 mg/kg) during 2 m...

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Published inAdvances in gerontology = Uspekhi gerontologii Vol. 24; no. 1; p. 143
Main Authors Muraleva, N A, Sadovoĭ, M A, Kolosova, N G
Format Journal Article
LanguageRussian
Published Russia (Federation) 2011
Subjects
Aging, Premature - blood
Aging, Premature - metabolism
Aging, Premature - prevention & control
Alendronate - administration & dosage
Alendronate - therapeutic use
Animals
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone Density - drug effects
Bone Density Conservation Agents - administration & dosage
Bone Density Conservation Agents - therapeutic use
Calcium - blood
Calcium - urine
Female
Male
Osteocalcin - blood
Osteoporosis - blood
Osteoporosis - metabolism
Osteoporosis - prevention & control
Rats
Rats, Wistar
Sex Characteristics
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Summary:The purpose of this research was to study the effect of Alendronate on bone mineral density (BMD) and markers of bone turnover in male and female Wistar rats and senescence-accelerated OXYS rats with early development of osteoporosis. The animals were treated with Alendronate (0.84 mg/kg) during 2 months from the age of 8 months. The effect of the drug depended on genotype and sex of animals. Alendronate increased the BMD and bone formation markers osteocalcin levels in the blood of female rats OXYS with low their initial level. In Wistar rats the drug increased bone mineral density only in males, while females reduced the level of osteocalcin. The level of serum calcium did not change, but its urinary excretion in Wistar male rats and in female rats of both strains was increased. The ability to influence on the development of disease by standard treatment shows that OXYS rats are suitable models to study the pathogenesis and design of new therapeutic targets of osteoporosis.
ISSN:1561-9125