High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl.LiCl and microwave irradiation

A wide range of functional aryl and heteroaryl zinc reagents have been efficiently prepared via regio- and chemoselective zincation using TMPZnCl.LiCl and microwave irradiation. Sensitive functional groups like esters are compatible with the high temperatures of the reactions. The resulting zinc spe...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) no. 37; pp. 5615 - 5617
Main Authors Mosrin, Marc, Monzon, Gabriel, Bresser, Tomke, Knochel, Paul
Format Journal Article
LanguageEnglish
Published England 07.10.2009
Subjects
Hot Temperature
JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors
JNK Mitogen-Activated Protein Kinases - metabolism
Lithium Chloride - chemistry
Microwaves
Protein Kinase Inhibitors - chemistry
Zinc - chemistry
Online AccessGet full text

Cover

More Information
Summary:A wide range of functional aryl and heteroaryl zinc reagents have been efficiently prepared via regio- and chemoselective zincation using TMPZnCl.LiCl and microwave irradiation. Sensitive functional groups like esters are compatible with the high temperatures of the reactions. The resulting zinc species undergo a number of subsequent reactions, providing highly functionalized aromatics and heteroaromatics in high yields.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1364-548X
DOI:10.1039/b913693b