Efficiency of radiation or chemoradiation therapy for diffusely growing brainstem tumors in children

Radiation or chemoradiation therapy was performed in 97 children with diffusely growing brainstem tumors. A reduction in the severity of neurological disorders was achieved in 92 (94.8%) patients. The course of the disease was traced in 79 patients. Control studies recorded no complete tumor regress...

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Bibliographic Details
Published inVestnik rentgenologii i radiologii no. 2-3; p. 4
Main Authors Shcherbenko, O I, Govorina, E V, Zelinskaia, N I, Parkhomenko, R A, Abbasova, E V, Rodionov, M V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2008
Subjects
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Humanized
Antineoplastic Agents - therapeutic use
Brain Stem Neoplasms - drug therapy
Brain Stem Neoplasms - mortality
Brain Stem Neoplasms - radiotherapy
Brain Stem Neoplasms - therapy
Chemotherapy, Adjuvant
Child
Dacarbazine - analogs & derivatives
Dacarbazine - therapeutic use
Disease Progression
Humans
Treatment Outcome
Vincristine - therapeutic use
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Summary:Radiation or chemoradiation therapy was performed in 97 children with diffusely growing brainstem tumors. A reduction in the severity of neurological disorders was achieved in 92 (94.8%) patients. The course of the disease was traced in 79 patients. Control studies recorded no complete tumor regression. Following 4-8 months, there was growth resumption of a tumor with its lysis and cyst formation in most children. The principal cause of death was local tumor progression. Six-month survivors were 64 (81%) patients; one-, two-, and three-survivors were 21 (26.5%), 8 (10.1%), and 3 (7.65) patients, respectively; one (2.8%) patient survived 5 years. A combination of radiotherapy and monochemotherapy with temodal, vincristine, oncofer, and theraloc failed to improve immediate and long-term results
ISSN:0042-4676