The variance of melphalan doses related to kilogram of body weight and the consequences

Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes...

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Published inKlinická onkologie Vol. 23; no. 6; p. 452
Main Author Vokurka, S
Format Journal Article
LanguageCzech
Published Czech Republic 2010
Subjects
Animals
Antineoplastic Agents, Alkylating - administration & dosage
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Alkylating - pharmacokinetics
Body Weight
Humans
Melphalan - administration & dosage
Melphalan - adverse effects
Melphalan - pharmacokinetics
Neoplasms - drug therapy
Stem Cell Transplantation
Online AccessGet more information

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Abstract Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes to increased oral toxicity and probably does not have any significant effect on treatment results within equally BSA (mg/m2) dosed melphalan regimens.
AbstractList Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes to increased oral toxicity and probably does not have any significant effect on treatment results within equally BSA (mg/m2) dosed melphalan regimens.
Author Vokurka, S
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DocumentTitleAlternate Variabilita dávek melfalanu vztazených na kilogram telesné hmotnosti a následky
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Snippet Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in...
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SubjectTerms Animals
Antineoplastic Agents, Alkylating - administration & dosage
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Alkylating - pharmacokinetics
Body Weight
Humans
Melphalan - administration & dosage
Melphalan - adverse effects
Melphalan - pharmacokinetics
Neoplasms - drug therapy
Stem Cell Transplantation
Title The variance of melphalan doses related to kilogram of body weight and the consequences
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Volume 23
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