The variance of melphalan doses related to kilogram of body weight and the consequences

Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes...

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Bibliographic Details
Published inKlinická onkologie Vol. 23; no. 6; p. 452
Main Author Vokurka, S
Format Journal Article
LanguageCzech
Published Czech Republic 2010
Subjects
Animals
Antineoplastic Agents, Alkylating - administration & dosage
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Alkylating - pharmacokinetics
Body Weight
Humans
Melphalan - administration & dosage
Melphalan - adverse effects
Melphalan - pharmacokinetics
Neoplasms - drug therapy
Stem Cell Transplantation
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Summary:Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes to increased oral toxicity and probably does not have any significant effect on treatment results within equally BSA (mg/m2) dosed melphalan regimens.
ISSN:0862-495X