Immunity to poliovirus after vaccination of children with type 1 diabetes mellitus and rheumatic diseases

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 5; p. 52
• Main Authors: Tarasova, A A, Kniagina, O N, Kalashnikova, N A, Kostinov, M P, Erukhimov, V L
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2009
• Subjects: Adolescent; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Child; Child, Preschool; Diabetes Mellitus, Type 1 - immunology; Female; Humans; Male; Mass Vaccination; Poliomyelitis - blood; Poliomyelitis - prevention & control; Poliovirus - immunology; Poliovirus Vaccine, Oral - administration & dosage; Rheumatic Diseases - immunology
• ISSN: 0372-9311

To assess immunization coverage against poliomyelitis and level of immunity postvaccination in children with type 1 diabetes mellitus (DM1) and rheumatic diseases. Vaccination status of 299 children with DM1 and 136 children with rheumatic diseases was determined. Serologic test using neutralization reaction was performed in 31 children with DM1 and 29 children with rheumatic diseases. Three hundred and eighty healthy children aged 3-14 years were included in the control group. All children previously received oral poliovirus vaccine. During postimmunization period decompensations of main disease in children with DM1 and rheumatic diseases were not observed. There were no seronegative children to all poliovirus types revealed. Proportion of children with DM1 and rheumatic diseases seronegative to two serotypes was 12.9% and 13.8% respectively. Proportion of children with DM1 seropositive to all 3 serotypes was 54.8% that is lower than in general population (p<0.01), whereas in children with rheumatic diseases this proportion was 75.8%. In children with DM1 real proportion of immune subjects was normal--94.9% and 82.0% for pqliovirus types 1 and 2 respectively, whereas the same proportion for poliovirus type 3 was 49.7%. In children with rheumatic diseases real proportion of immune subjects was normal for poliovirus types 1 and 2, and was 72.4% for poliovirus type 3. Algorithms of examination of patientswith DM1 and rheumatic diseases, which allow to purposefully perform serologic evaluation as well as recommendations about additional immunization against poliomyelitis, were developed.