Rol of pituitary tumour-transforming gene (PTTG) in the pituitary adenomas

The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm a...

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Published inEndocrinologia y nutricion Vol. 57; no. 1; p. 28
Main Authors Sánchez-Ortiga, Ruth, Sánchez Tejada, Laura, Peiró Cabrera, Gloria, Moreno-Pérez, Oscar, Arias Mendoza, Nieves, Aranda López, F Ignacio, Picó Alfonso, Antonio
Format Journal Article
LanguageSpanish
Published Spain 01.01.2010
Subjects
Humans
Neoplasm Proteins - genetics
Pituitary Neoplasms - genetics
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Summary:The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours.
ISSN:1575-0922
DOI:10.1016/S1575-0922(10)70006-1