Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclase C receptor-deficient mice

We studied the functional importance of the colonic guanylyl cyclase C (GCC) receptor in GCC receptor-deficient mice. Mice were anesthetized with pentobarbital sodium, and colon segments were studied in Ussing chambers in HCO-3 Ringer under short-circuit conditions.

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Bibliographic Details
Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 43; no. 2; pp. G216 - G221
Main Authors CHARNEY, Alan N, EGNOR, Richard W, ALEXANDER-CHACKO, Jesline T, ZAHARIA, Valentin, MANN, Elizabeth A, GIANNELLA, Ralph A
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.2001
Subjects
Bacteria
Bacterial diseases
Biological and medical sciences
Colon
Digestive system
Experimental bacterial diseases and models
Infectious diseases
Ions
Medical sciences
Rodents
Digestive system
Enzyme
Deficiency
Escherichia coli
Biological transport
Gut
Rodentia
Phosphorus-oxygen lyases
Chlorine ion
Lyases
Guanylate cyclase
Vertebrata
Anions
Mammalia
Electrolyte
Mouse
Animal
Sodium ion
Enterotoxin
Bacteria
Colon
Exocrine secretion
Enterobacteriaceae
Biological receptor
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Summary:We studied the functional importance of the colonic guanylyl cyclase C (GCC) receptor in GCC receptor-deficient mice. Mice were anesthetized with pentobarbital sodium, and colon segments were studied in Ussing chambers in HCO-3 Ringer under short-circuit conditions.
ISSN:0193-1857
1522-1547