N-acetylcysteine in septic shock

To focus on the various studies evaluating the effects of Nacetylcysteine in septic shock Main references obtained from the medical database Medline using the keywords: N-acetylcysteine; septic shock, free radicals. Septic shock remains the leading cause of mortality in intensive care units. The pro...

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Bibliographic Details
Published inTunisie Medicale Vol. 89; no. 10; p. 738
Main Authors Ellouze, Omar, Frikha, Nabil, Ouerghi, Sonia, Mestiri, Taher, Salah Ben Ammar, Mohamed
Format Journal Article
LanguageFrench
Published Tunisia 01.10.2011
Subjects
Acetylcysteine - pharmacology
Acetylcysteine - therapeutic use
Free Radical Scavengers - pharmacology
Free Radical Scavengers - therapeutic use
Humans
Shock, Septic - drug therapy
Shock, Septic - physiopathology
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Summary:To focus on the various studies evaluating the effects of Nacetylcysteine in septic shock Main references obtained from the medical database Medline using the keywords: N-acetylcysteine; septic shock, free radicals. Septic shock remains the leading cause of mortality in intensive care units. The progressive knowledge of the pathophysiology of septic shock, underline the production of free radicals and their cellular and microcirculatory effects. The Nacetylcysteine used mainly in paracetamol poisoning, has properties to control free radicals. The explosion of free radicals in septic shock has led to multiple studies assessing the role of N-acetylcysteine as an anti radical, and for its anti inflammatory action. NAC seems to play an important role in septic shock to control free radicals and the inflammatory response. But these results remain contradictory. Some larger and more standardized studies should allow to evaluate the actual effects of NAC in septic shock.
ISSN:0041-4131