The cytokines profile at the enterobacter pneumonia during experiment

• Published in: Patologicheskaia fiziologiia i eksperimental'naia terapiia no. 4; p. 27
• Main Authors: Kostiushko, A V, Markelova, E V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.10.2010
• Subjects: Animals; Disease Models, Animal; Enterobacter; Enterobacteriaceae Infections - immunology; Enterobacteriaceae Infections - metabolism; Enterobacteriaceae Infections - microbiology; Humans; Interferon-gamma - immunology; Interferon-gamma - metabolism; Interleukin-10 - immunology; Interleukin-10 - metabolism; Mice; Pneumonia, Bacterial - immunology; Pneumonia, Bacterial - metabolism; Pneumonia, Bacterial - microbiology
• ISSN: 0031-2991

Distinctions between system and local levels of cytokines and dynamics of their development depending on ethiology of pneumonia were established during experiment. It proved that the enterobacter pneumonia is accompanied by raised systematic IFNgamma production and essentially increased IL-10 production, whereas with the pneumonia caused by E. coli, the IFNgamma production level differs little from control values, and IL-10 is statistically more less its values in intact animals blood. The local level of cytokines at the pneumonia caused by Enterobacter spp. is characterized by the early significant IL-10 production activation and expressed IFNgamma production depression a fortmight later two weeks after infection. Increasing local IL-10 production prevalence is registered when mice contaminating with E. coli. Thus, the experimental pneumonias caused by Enterobacter spp. and E. coli are characterized by cytokines' system disbalance that renders expressed immunodepressive influence on pulmonary factors of protection and it's necessary for choosing methods pneumonia's pathogenetic therapy.