Isoform-specific regulation of the lactate transporters MCT1 and MCT4 by contractile activity

We examined the isoform-specific regulation of monocarboxylate transporter (MCT)1 and MCT4 expression by contractile activity in red and white tibialis anterior muscles. After 1 and 3 wk of chronic muscle stimulation (24 h/day), MCT1 protein expression was increased in the red muscles (+78%, P<0....

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Published inAmerican journal of physiology: endocrinology and metabolism Vol. 42; no. 5; pp. E1131 - E1138
Main Authors BONEN, Arend, TONOUCHI, Mio, MISKOVIC, Dragana, HEDDLE, Catherine, HEIKKILA, John J, HALESTRAP, Andrew P
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.11.2000
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Metabolism
Muscular system
Proteins
Ribonucleic acid
RNA
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
Molecular form
Rat
Rodentia
Red striated muscle
Muscular fiber
Gene expression
Anterior tibial muscle
Muscle contraction
Lactates
Vertebrata
Mammalia
Animal
Carrier protein
White striated muscle
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Summary:We examined the isoform-specific regulation of monocarboxylate transporter (MCT)1 and MCT4 expression by contractile activity in red and white tibialis anterior muscles. After 1 and 3 wk of chronic muscle stimulation (24 h/day), MCT1 protein expression was increased in the red muscles (+78%, P<0.05).
ISSN:0193-1849
1522-1555