Feeding purified glycerol from biodiesel to CBA/CA mice: effects on Gadd45a and Nfkappab1 expressions
The turn towards renewable energy sources has increased the production of biodiesel from rapeseed oil, leaving glycerol as a valuable by-product. Several studies have evaluated this product in feed for poultry, swine and ruminants. We investigated the effect of these glycerol products on the express...
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Published in | In vivo (Athens) Vol. 24; no. 3; pp. 303 - 307 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Greece
01.05.2010
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Subjects | |
Online Access | Get full text |
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Summary: | The turn towards renewable energy sources has increased the production of biodiesel from rapeseed oil, leaving glycerol as a valuable by-product. Several studies have evaluated this product in feed for poultry, swine and ruminants. We investigated the effect of these glycerol products on the expression of DNA damage-inducible genes in mice.
CBA/CA mice were administered two different purified glycerol products (SZME2, SZME3) for 3, 6 and 24 hours. After dietary exposure, gene expressions of nuclear factor kappa-light-chain-enhancer of activated B-cells 1 (NFkb1) and growth arrest and DNA-damage-inducible protein 45 alpha (Gadd45a) were analysed.
SZME2 induced a down-regulation of the two genes in all investigated organs, including the bone marrow in both genders. After administration of SZME3, up-regulation of the two genes was observed in bone marrow in males, and the up-regulation of Gadd45a in liver, also in males.
Based upon our data, SZME3, which contains glycerol of higher purification, did not induce down-regulation in genes which are involved in apoptosis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0258-851X |