Cancer microenvironment affects biological properties of tumor cells--tumor as an embryologic problem?

Mutual epithelial-mesenchymal interaction represents a fundamental control mechanism during the development of organs and tissues. This review article demonstrates the importance of such interaction for tumor formation where it influences the biological properties of cancer stem cell and tumor itsel...

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Bibliographic Details
Published inČasopis lékařů českých Vol. 149; no. 12; p. 572
Main Authors Smetana, Karel, Dvoránková, Barbora, Lacina, Lukás, Krejcí, Eliska, Grim, Milos
Format Journal Article
LanguageCzech
Published Czech Republic 2010
Subjects
Animals
Cell Transformation, Neoplastic
Humans
Melanoma - embryology
Neoplasms - embryology
Neoplasms - physiopathology
Neoplastic Stem Cells - physiology
Teratoma - embryology
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Summary:Mutual epithelial-mesenchymal interaction represents a fundamental control mechanism during the development of organs and tissues. This review article demonstrates the importance of such interaction for tumor formation where it influences the biological properties of cancer stem cell and tumor itself. The teratoma and melanoma are employed as examples to demonstrate the influence of embryonic microenvironment on the biological properties of tumor, mainly on its potential to metastasize. The manipulation of cancer microenvironment represents the perspective therapeutic tool for cancer treatment in future.
ISSN:0008-7335