Polymorphism of repair genes and cytogenetic radiation effects

For 99 healthy volunteers, the frequencies of spontaneous and y-induced (1 Gy in vitro) chromosome aberrations in blood lymphocytes were compared with the results of PCR-genotyping by 8 repair genes: XRCC1, XPD, ERCC1, APEXI, RAD23B, OGG1, ATM, Tp53 (in all, 10 polymorphic sites). The frequency of s...

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Published inRadiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 50; no. 6; p. 656
Main Authors Sal'nikova, L E, Chumachenko, A G, Vesnina, I N, Lapteva, N Sh, Kuznetsova, G I, Abilev, S K, Rubanovich, A V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2010
Subjects
Adult
Alleles
Chromosome Aberrations - radiation effects
Cytogenetic Analysis
DNA Repair - genetics
DNA Repair - radiation effects
Gamma Rays
Genotype
Humans
In Vitro Techniques
Lymphocytes - radiation effects
Male
Polymorphism, Genetic
Young Adult
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Summary:For 99 healthy volunteers, the frequencies of spontaneous and y-induced (1 Gy in vitro) chromosome aberrations in blood lymphocytes were compared with the results of PCR-genotyping by 8 repair genes: XRCC1, XPD, ERCC1, APEXI, RAD23B, OGG1, ATM, Tp53 (in all, 10 polymorphic sites). The frequency of spontaneous aberrations of chromosome type increased additively with the number of copies of minor allele of excision repair gene XPD variant *2251G and *862A D (p = 0.025). The frequency of gamma-induced chromosome aberrations proved to be elevated for the carriers of a minor allele OGG1*977G (p = 0.011). The significantly elevated number of gamma-induced chromosome aberrations was also observed for the carriers of major alleles XRCC1*G1996 and XRCC1*C589 (p = 0.002).
ISSN:0869-8031