Lanzoptol efficacy at gastroesophageal reflux disease: results of multicenter study leader

Results of multicenter study "Efficacy of Lansoptol (lansoprazole, KRKA) and its influence on the Dynamics of GERD symptoms" (LIEDER) are presented. The impact of 56-days treatment with lansoprazole 30 mg once daily on symptoms relief, a quality of life of 121 patients with gastroesophagea...

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Published inĖksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 7; p. 112
Main Authors Lazebnik, L B, Bordin, D S, Masharova, A A, V'iuchnova, E S, Zakharova, N V, Abdulkhakov, R A, Prokhorova, L V, Nikolaeva, N N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2010
Subjects
2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage
2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects
Adult
Endoscopy, Digestive System
Enzyme Inhibitors - administration & dosage
Enzyme Inhibitors - adverse effects
Female
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - pathology
Humans
Hydrogen-Ion Concentration
Lansoprazole
Male
Middle Aged
Remission Induction
Time Factors
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Summary:Results of multicenter study "Efficacy of Lansoptol (lansoprazole, KRKA) and its influence on the Dynamics of GERD symptoms" (LIEDER) are presented. The impact of 56-days treatment with lansoprazole 30 mg once daily on symptoms relief, a quality of life of 121 patients with gastroesophageal reflux disease (GERD) and healing of esophageal lesions of 30 patients with reflux esophagitis were investigated. Rapid acid inhibition effect of first dose of lansoptol was shown by 48-hr pH-monitoring. At the first day of the treatment 43.1% of patients reported decreasing of intensity of heartburn and 36.5%--of regurgitation. It were shown that the treatment with lansoptol provided symptoms relief in 25% patients at day 3, in 50% of patients at day 5 and in 75% at day 8 for heartburn, and at days 2, 6 and 9--for regurgitation. It was conducted improvement of quality of life. Healing rate of esophagitis at 28 day was 83.3%.
ISSN:1682-8658