Influence of complex compounds on the activity of antioxidant enzymes in neoplastic diseases of the digestive tract

• Published in: Polski merkuriusz lekarski Vol. 27; no. 158; p. 97
• Main Authors: Malinowska, Katarzyna, Modranka, Roman, Kubiak, Katarzyna, Klimczak, Alicja, Mrowicka, Małgorzata, Mrowicki, Jerzy
• Format: Journal Article
• Language: Polish
• Published: Poland 01.08.2009
• Subjects: Aged; Antineoplastic Agents - pharmacology; Antioxidants - pharmacology; Catalase - blood; Catalase - drug effects; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - enzymology; Digestive System Neoplasms - drug therapy; Digestive System Neoplasms - enzymology; Erythrocytes - enzymology; Female; Humans; Male; Organometallic Compounds - pharmacology; Stomach Neoplasms - drug therapy; Stomach Neoplasms - enzymology
• ISSN: 1426-9686

Chemotherapy is an important field of clinical medicine and pharmacology Chemotherapy is the main method of treating the neoplasm. It involves treating the neoplastic disease with the use of natural or synthetic anticancer drugs commonly known as the cytostatics. The cancer therapy involving the cytostatics is a difficult and not always effective process, which requires taking into consideration the mechanisms of action, pharmacokinetics and the dosage schemas. The complexity of the chemotherapy is influenced by: still incomplete knowledge of causes of neoplasm formation, slight biological differences between the cancer cells and the regular cells, very small selectivity of cytostatics' action, narrow therapeutic index of the anticancer drugs, high toxicity for healthy cells and unsatisfactory anticancer activity. The aim of the study was to obtain the complex compounds of copper (II), and especially of dinitrate (V) di (3,4, 5-trimethyl-N1-pyrazol-kappaN2) copper (II), and its subsequent testing for pro- and antioxidative activity in people suffering from neoplastic diseases of the digestive tract (colorectal and gastric carcinoma). Material and methods. The activity of catalase was determined in erythrocytes patients suffering from colorectal and gastric carcinoma and in control group (hernia, chronic gastric ulcer disease and haemorrhoids) using the method of Beers and Sizer at 240 nm on the Beckman spectrophotometer. The results of the test on catalase in patients suffering from colorectal and gastric carcinoma indicate that the addition to the blood of the complex compound of Cu(II) significantly influences the activity of the enzyme in comparison with the control group in which the substance tested was not used. In the tests a marked statistical difference was observed between the studied and the control group. The results reveal that chemical compounds, that is, dinitrate (V) di (3,4,5-trimethyl-N1-pyrazol-kappaN2) copper (II), has a significant influence on the activity of catalase, the antioxidant enzyme.