Possibilities for the correction of immune disorders during tuberculosis infection

Modem immunopathogenetic concepts of tuberculosis infection are summarized. Th1-mediated immune response is shown to play a leading role in the formation of antituberculosis immunity. Cytokine balance (especially that of interferon-y) has marked influence on the outcome of infection. The data on eff...

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Bibliographic Details
Published inKlinicheskaia meditsina Vol. 88; no. 6; p. 14
Main Authors Sukhanov, D S, Ivanov, A K, Romantsev, M G, Kovalenko, A L, Demidik, S N, Kuchko, I V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2010
Subjects
Humans
Immune System Diseases - drug therapy
Immune System Diseases - etiology
Immune System Diseases - immunology
Immunity, Cellular
Immunologic Factors - therapeutic use
Tuberculosis - complications
Tuberculosis - drug therapy
Tuberculosis - immunology
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Summary:Modem immunopathogenetic concepts of tuberculosis infection are summarized. Th1-mediated immune response is shown to play a leading role in the formation of antituberculosis immunity. Cytokine balance (especially that of interferon-y) has marked influence on the outcome of infection. The data on efficiency of modern immunotropic drugs suggest advantages of interferon inductors, in the first place cyclopheron, for pathogenetic therapy. Cyclopheron participates in regulation of endogenous interferon-gamma production and thereby in activation of TH1-mediated immune response that accelerates abacillation, closes cavities in organs undergoing degeneration, and improves the X-ray picture. A succinate-containing cyclopheron solution was shown to positively change the cytokine profile and X-ray structure of respiratory organs in patients with tuberculosis.
ISSN:0023-2149