Analysis of genetic predisposition to pulmonary tuberculosis in native Russians

Tuberculosis (TB) is one of the most important concerns of public health. There is evidence suggesting that genetic status is responsible for predisposition to infectious diseases including TB. To determine genetic risk factors of TB development, the frequencies of polymorphisms of genes CYP1A1, CYP...

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Bibliographic Details
Published inGenetika Vol. 46; no. 2; p. 262
Main Authors Gra, O A, Kozhekbaeva, Zh M, Litvinov, V I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.2010
Subjects
Adult
Aged
Aged, 80 and over
Alleles
ATP Binding Cassette Transporter, Sub-Family B
ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
Cation Transport Proteins - genetics
Cohort Studies
Cytochrome P-450 Enzyme System - genetics
Female
Gene Frequency - genetics
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Genotype
Glutathione Transferase - genetics
Humans
Male
Middle Aged
Moscow - epidemiology
Moscow - ethnology
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - genetics
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Summary:Tuberculosis (TB) is one of the most important concerns of public health. There is evidence suggesting that genetic status is responsible for predisposition to infectious diseases including TB. To determine genetic risk factors of TB development, the frequencies of polymorphisms of genes CYP1A1, CYP2D6, CYP2C9, CYP2C 19, GSTT1, GSTM1, NAT2, MDR1, and NRAMP1 in 73 TB patients and 352 healthy individuals were determined by allele-specific hybridization using microarray technology. The TB patients have shown a significant increase in the frequency of the null GSTT1 genotype (OR = 3.26, 95% CI = 1.91 - 5.55, p = = 0.000028) as well as the double null GSTT1/GSTM1 genotype (OR = 4.05, 95% CI = 2.14 -7.65, p = = 0.000034) compared to the group of healthy donors. It was shown that the NAT2*5/*5 genotype in combination with the "null" GSTT1 and the double "null" GSTT1/GSTM1 genotypes was observed significantly more often in the TB patients than in the control sample. Thus the examined GSTT1, GSTM1 and NAT2 gene polymorphisms may potentially alter the risk of TB development in ethnic Russians and are of interest for further research using larger cohorts of patients.
ISSN:0016-6758