Free radical oxidation of lipids in the rat hypothalamus under stress after cortisol pretreatment

Free radical oxidation of lipids in the rat hypothalamus after cortisol pretreatment weas investigated. Three-fold cortisol injection (25 mg/kg, once per day) resulted in significant decrease of average level of Schiffbases, the final products of lipid oxidation. Stress causes increase of average le...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 97; no. 9; p. 898
Main Authors Flerov, M A, V'iushina, A V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2011
Subjects
Animals
Electric Stimulation
Free Radicals - metabolism
Hydrocortisone - administration & dosage
Hydrocortisone - pharmacology
Hypothalamus - drug effects
Hypothalamus - metabolism
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
Lipids - analysis
Lipids - chemistry
Male
Rats
Rats, Wistar
Schiff Bases - metabolism
Stress, Physiological
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Summary:Free radical oxidation of lipids in the rat hypothalamus after cortisol pretreatment weas investigated. Three-fold cortisol injection (25 mg/kg, once per day) resulted in significant decrease of average level of Schiffbases, the final products of lipid oxidation. Stress causes increase of average level of Schiff bases in the control animals (without cortisol pretreatment). Cortisol pretreatment potentiated stress-induced changes in the processes of free radical oxidation of lipids in the rats hypothalamus.
ISSN:0869-8139