Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue

Strange et al found that after injection of Xenopus oocytes with K-Cl cotransporters (KCC) cRNA induced a 20-fold increase in Cl- dependent, furosemide-sensitive K+ uptake. They postulate that the carboxy terminus plays an essential role in maintaining the functional conformation of KCC cotransporte...

Full description

Saved in:
Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 48; no. 3; pp. C860 - C867
Main Authors STRANGE, K, SINGER, T. D, MORRISON, R, DELPIRE, E
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2000
Subjects
Biochemistry
Biological and medical sciences
Cell physiology
Cells
Cellular biology
Fundamental and applied biological sciences. Psychology
Membrane and intracellular transports
Molecular and cellular biology
Proteins
Tyrosine
Conserved sequence
Neuron
Chlorides
KCC2 cotransporter
Ion transport
Coupled transport
Gene expression
In vitro
Potassium
Carrier protein
Online AccessGet full text

Cover

More Information
Summary:Strange et al found that after injection of Xenopus oocytes with K-Cl cotransporters (KCC) cRNA induced a 20-fold increase in Cl- dependent, furosemide-sensitive K+ uptake. They postulate that the carboxy terminus plays an essential role in maintaining the functional conformation of KCC cotransporters and/or is involved in essential regulatory protein-protein interactions.
ISSN:0363-6143
1522-1563