Effects of chronic administration of moxonidine in hypertensive rats SHR-SP

Study of the hemodynamic response (arterial pressure and heart rate) by radio- and telemetric techniques in stroke-prone hypertensive rats (SHR-SP) aged 6-7 months showed that a chronic oral administration of moxonidine at a daily dose of 2 and 10 mg/kg) leads to hypotension (7 +/- 3 and 21 +/- 5%,...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 63; no. 5; p. 21
Main Authors Khokhlova, O N, Murashev, A N, Lavrova, L N, Medvedev, O S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2000
Subjects
Animals
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - pharmacology
Antihypertensive Agents - toxicity
Blood Pressure - drug effects
Bradycardia - chemically induced
Circadian Rhythm
Dose-Response Relationship, Drug
Heart Rate - drug effects
Hypotension - chemically induced
Imidazoles - administration & dosage
Imidazoles - pharmacology
Imidazoles - toxicity
Male
Motor Activity - drug effects
Rats
Rats, Inbred SHR
Substance Withdrawal Syndrome - physiopathology
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Summary:Study of the hemodynamic response (arterial pressure and heart rate) by radio- and telemetric techniques in stroke-prone hypertensive rats (SHR-SP) aged 6-7 months showed that a chronic oral administration of moxonidine at a daily dose of 2 and 10 mg/kg) leads to hypotension (7 +/- 3 and 21 +/- 5%, respectively) and bradycardia (5 +/- 1 and 14 +/- 5%, respectively). The moxonidine administration at a greater dose violated the circadian heart rate profile, reduced the motor activity of rats by 34 +/- 15%, and showed a drug dependence syndrome in the heart rate (but not in the arterial pressure). It is concluded that moxonidine administration at large doses may give rise to side effects.
ISSN:0869-2092