Normalization of up-regulated cardiac imidazoline I(1)-receptors and natriuretic peptides by chronic treatment with moxonidine in spontaneously hypertensive rats

The effect of treatment with moxonidine (120 mg/kg/h sc, 4 weeks) on cardiac I(1)-receptors and natriuretic peptide synthesis was evaluated in spontaneously hypertensive rats (SHR). I(1)-receptor protein (85 kD) was up-regulated in SHR atria, and normalized in right and left atria by moxonidine. Sim...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 1009; pp. 274 - 278
Main Authors El-Ayoubi, R, Menaouar, A, Gutkowska, J, Mukaddam-Daher, S
Format Journal Article
LanguageEnglish
Published United States 01.12.2003
Subjects
Animals
Atrial Natriuretic Factor - genetics
Atrial Natriuretic Factor - metabolism
Female
Heart Atria - metabolism
Imidazoles - administration & dosage
Imidazoles - pharmacology
Imidazoline Receptors
Natriuretic Peptide, Brain - genetics
Natriuretic Peptide, Brain - metabolism
Rats
Rats, Inbred SHR
Rats, Sprague-Dawley
Receptors, Drug - metabolism
Up-Regulation
Ventricular Function
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Summary:The effect of treatment with moxonidine (120 mg/kg/h sc, 4 weeks) on cardiac I(1)-receptors and natriuretic peptide synthesis was evaluated in spontaneously hypertensive rats (SHR). I(1)-receptor protein (85 kD) was up-regulated in SHR atria, and normalized in right and left atria by moxonidine. Similarly, moxonidine normalized atrial and ventricular atrial natriuretic peptide messenger RNA (mRNA) and brain natriuretic peptide mRNA. This study shows that cardiac I(1)-receptors are functional, being regulated by hypertension and by chronic exposure to agonist, and that cardiac natriuretic peptides may be regulated by I(1)-receptor-mediated mechanisms.
Bibliography:ObjectType-Article-1
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ISSN:0077-8923
1749-6632