Diagnosis of hemochromatosis with magnetic resonance

Hemochromatosis is a disorder of parenchymal iron overload. The diagnosis is based upon clinical manifestations, laboratory findings and iron concentration in liver. Magnetic resonance imaging (MRI) shows a decrease in liver signal intensity. Its role has not been already defined. Nonetheless, ratio...

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Bibliographic Details
Published inAnales de medicina interna (Madrid, Spain : 1984) Vol. 17; no. 8; p. 419
Main Authors Larrubia, J R, Mendoza, J L, Pérez de la Serna, J A, Ruiz de León, A, Méndez, R, Díaz-Rubio, M
Format Journal Article
LanguageSpanish
Published Spain 01.08.2000
Subjects
Aged
Hemochromatosis - diagnosis
Humans
Liver Diseases - diagnosis
Magnetic Resonance Imaging
Male
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Summary:Hemochromatosis is a disorder of parenchymal iron overload. The diagnosis is based upon clinical manifestations, laboratory findings and iron concentration in liver. Magnetic resonance imaging (MRI) shows a decrease in liver signal intensity. Its role has not been already defined. Nonetheless, ratio of liver to muscle proton density (LMPD) shows a significant correlation with hepatic iron. One patient with a long-standing cirrhosis with data of hemochromatosis whose coagulation study did not allow to perform a liver biopsy was diagnosed with this method. Hepatic iron concentration was calculated based upon: microgram/g of hepatic iron = (-5.174* LMPD) + 9.932. MRI can be useful in the evaluation of hemochromatosis among patients who refuse or have contraindication to liver biopsy.
ISSN:0212-7199