Predicting individual reactions to emotional stress and benzodiazepine tranquilizers

The results of pharmacogenetic experiments revealed specificity of the emotional-stress reactions (ESR) in the inherited deterministic type of behavior and showed dependence of the benzodiazepine tranquilizer action on the ESR phenotype. Based on these data, we carried out experiments with a group o...

Full description

Saved in:
Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 64; no. 1; p. 3
Main Authors Seredenin, S B, Badyshtov, B A, Neznamov, G G, Makhnycheva, A L, Kolotilinskaia, N V, Nadorov, S A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2001
Subjects
Adult
Anti-Anxiety Agents - pharmacology
Benzodiazepines
Cluster Analysis
Data Interpretation, Statistical
Hormones - blood
Humans
Male
Middle Aged
Personality Assessment
Pharmacogenetics
Phenotype
Prognosis
Psychomotor Performance
Stress, Psychological - blood
Stress, Psychological - genetics
Stress, Psychological - psychology
Online AccessGet more information

Cover

More Information
Summary:The results of pharmacogenetic experiments revealed specificity of the emotional-stress reactions (ESR) in the inherited deterministic type of behavior and showed dependence of the benzodiazepine tranquilizer action on the ESR phenotype. Based on these data, we carried out experiments with a group of volunteers performing operator functions in a model of emotional-stress conditions. The results of these experiments allowed the operators to be divided into stress-resistant and stress-affected groups. The results of the data processing by methods of multidimensional statistics showed possibility of predicting the ESR phenotype and the qualitative effect of phenazepam (0.5 mg. p.o.) based on the individual topological and hormonal-biochemical characteristics of operators.
ISSN:0869-2092