Changes in nitric oxide in heart of intact and sympathectomized rats of different age

Nitric oxide production in heart tissues of rats of different age in the norm and after pharmacological sympathectomy was studied by electron spin resonance spin-trapping. Rats at the age of 14, 21, 70, and 100 days were used in the experiment. The concentration of nitric oxide produced in rat heart...

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Bibliographic Details
Published inOntogenez Vol. 39; no. 6; p. 437
Main Authors Adrianov, V V, Sitdikov, F G, Gaĭnutdinov, Kh L, Iurtaeva, S V, Iafarova, G G, Muranova, L N, Obynochnyĭ, A A, Karimov, F K, Chiglintsev, V M, Iiudin, V S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2008
Subjects
Aging - metabolism
Animals
Myocardium - metabolism
Nitric Oxide - metabolism
Rats
Sympathectomy, Chemical - methods
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Summary:Nitric oxide production in heart tissues of rats of different age in the norm and after pharmacological sympathectomy was studied by electron spin resonance spin-trapping. Rats at the age of 14, 21, 70, and 100 days were used in the experiment. The concentration of nitric oxide produced in rat heart tissues proved to considerably decrease during ontogeny. Pharmacological sympathectomy notably decreased nitric oxide production in the heart in 14- and 21-day-old rats: the nitric oxide concentration in the spin trap as well as the level of R and T conformers of hemoglobin nitrosyl complexes decreased. In 70-day-old rats, pharmacological sympathectomy had no notable effect on the level of nitric oxide-containing paramagnetic complexes.
ISSN:0475-1450