Estimation of age-related changes in the regulation of peripheral blood flow in humans

The age-dependent features in the state of skin microvascular bed has been studied with laser Doppler flowmetry in healthy volunteers of different age groups. To reveal the reaction of skin blood flow in response to short-term ischemia, the occlusive test has been carried out. To estimate the contri...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 91; no. 11; p. 1305
Main Authors Tikhonova, I V, Tankanag, A V, Kosiakova, N I, Chemeris, N K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2005
Subjects
Adult
Aged
Aging - physiology
Endothelium, Vascular - physiology
Humans
Ischemia - physiopathology
Laser-Doppler Flowmetry
Microcirculation - innervation
Microcirculation - physiology
Middle Aged
Muscle, Smooth, Vascular - physiology
Regional Blood Flow
Skin - blood supply
Vasodilation - physiology
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Summary:The age-dependent features in the state of skin microvascular bed has been studied with laser Doppler flowmetry in healthy volunteers of different age groups. To reveal the reaction of skin blood flow in response to short-term ischemia, the occlusive test has been carried out. To estimate the contribution of rhythmic components to blood flow signal, continuous wavelet-transform spectral analysis was used. Age-dependent increase of pulse-wave amplitude and decrease of respiratory wave amplitude reflecting age-dependent changes in functioning of arteriolar and venular links of microvascular bed have been observed at rest. In response to short-term ischemia the age-dependent reduction of reserve resources has been revealed in functioning of arteriolar link of microvascular bed. The reduction of activity of myogenic, neurogenic and endothelial regulation systems have been shown at rest in ageing.
ISSN:0869-8139