Detection of lymphoproliferative response in monkeys innoculated with dengue 4 virus

A group of 6 Cynomolgus monkeys was immunized with dengue 4 virus (H247 standard strain). 60 days after innoculation the cellular proliferation against the same serotype as well as against hetereologous serotypes 1 and 2 was measured. A proliferative response predominantly of the specific serotype a...

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Published inRevista cubana de medicina tropical Vol. 55; no. 1; pp. 27 - 29
Main Authors García, Gissel, Alvarez, Mailing, Santana, Elaine, Martínez, José Rafael, Alvarez, Alejandro, Rodríguez, Rosmary, Guzmán, María G
Format Journal Article
LanguageSpanish
Published Cuba 01.01.2003
Subjects
Animals
Dengue - immunology
Dengue Virus - classification
Dengue Virus - immunology
Lymphocytes - immunology
Macaca fascicularis
Serotyping
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Summary:A group of 6 Cynomolgus monkeys was immunized with dengue 4 virus (H247 standard strain). 60 days after innoculation the cellular proliferation against the same serotype as well as against hetereologous serotypes 1 and 2 was measured. A proliferative response predominantly of the specific serotype and some cross reactivity were detected. These results showed a behavior of primates similar in some extent to that of human beings and mice regarding the specific serotype and cross serotype response to dengue virus.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0375-0760