The enterosorbents belosorb and panzysorb in the treatment of acute experimental pancreatitis in rats

Enterosorption with highly dispersed fibrous carbon adsorbent Belosorb or enzyme-containing fibrous carbon adsorbent Panzysorb was applied for the treatment of experimental acute pancreatitis (EAP) in the rats. Panzysorb was obtained by immobilization of digestive hydrolases (proteases and amylase)...

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Bibliographic Details
Published inFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 46; no. 1; pp. 101 - 108
Main Authors Hurina, N M, Iurchenko, O V, Nikolaiev, V H
Format Journal Article
LanguageUkrainian
Published Ukraine 2000
Subjects
Acute Disease
Animals
Carbon - therapeutic use
Enterosorption - methods
Enzymes - therapeutic use
Evaluation Studies as Topic
Female
Pancreas - pathology
Pancreatitis - pathology
Pancreatitis - therapy
Rats
Time Factors
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Summary:Enterosorption with highly dispersed fibrous carbon adsorbent Belosorb or enzyme-containing fibrous carbon adsorbent Panzysorb was applied for the treatment of experimental acute pancreatitis (EAP) in the rats. Panzysorb was obtained by immobilization of digestive hydrolases (proteases and amylase) on Belosorb as matrix. It was shown that oral administration of Panzysorb (100 mg/kg body weight) significantly decreased amylolytic and lipolytic activity of blood serum by the third hour after EAP induction. The course of enterosorption (ten days) with the Panzysorb led to the appearance of regeneration focuses in injured organ.
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ISSN:2522-9028