Sex influences on opioid pharmacotherapy

Opioids make up a pharmacological group employed from antiquity for the treatment of various ailments. Nowadays they are far used like palliative of acute or chronic pains of high intensity considering their great analgesic effectiveness. During the last years, many articles have reported sex-relate...

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Bibliographic Details
Published inVertex (Buenos Aires, Argentina) Vol. 18; no. 76; p. 413
Main Author Díaz, Silvina L
Format Journal Article
LanguageSpanish
Published Argentina 01.11.2007
Subjects
Adult
Drug Therapy - methods
Drug Therapy - statistics & numerical data
Female
Gonadal Steroid Hormones - blood
Humans
Male
Opioid-Related Disorders - epidemiology
Opioid-Related Disorders - rehabilitation
Sex Distribution
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Summary:Opioids make up a pharmacological group employed from antiquity for the treatment of various ailments. Nowadays they are far used like palliative of acute or chronic pains of high intensity considering their great analgesic effectiveness. During the last years, many articles have reported sex-related differences in the response of laboratory animals to several opioids. These data is according to the knowledge about sex determining both brain structure and functions. In addition, this sexual dimorphism has been recently reported for women and men treated with opioids. The relevance of this information could give rise to a revision of the dosage traditionally employed by physicians in either sex. The present article covers the main aspects of this subject considering its significance in the pharmacotherapy with opioids.
ISSN:0327-6139